molecular weight semaglutide approximately 4113.58 g/mol - 7ki0 structure Unveiling the Molecular Weight of Semaglutide: A Comprehensive Chemical Profile

Semaglutidesequence Semaglutide, a potent glucagon-like peptide-1 (GLP-1) receptor agonist, has garnered significant attention for its efficacy in managing type 2 diabetes and promoting weight loss.Molecular Weight.846.10; Formula. C43H79N3O ; CAS No. 1118767-16-0 ; Appearance. Liquid ; Color. Colorless to off-white. Understanding its intricate molecular weight is fundamental to comprehending its chemical properties, synthesis, and biological interactions. This article delves into the precise molecular weight of semaglutide, exploring its chemical formula, structure, and the implications of these characteristicsCID 122189768 | C187H291N45O59 - PubChem.

The molecular formula of semaglutide is consistently reported as C187H291N45O59. This complex formula signifies a molecule composed of 187 carbon atoms, 291 hydrogen atoms, 45 nitrogen atoms, and 59 oxygen atoms. This substantial composition is indicative of a peptide-based drug, which is further illuminated by its characteristic structure.MOLECULAR FORMULA C187H291N45O59;MOLECULAR WEIGHT 4113.64· Des-Gly-31-Semaglutide. MOLECULAR FORMULA C185H288N44O58; MOLECULAR WEIGHT 4056.59 · γ-Glu(3)- ... Semaglutide is a synthetic peptide that comprises 31 amino acids. Its derivation from human GLP-1 means it shares a high degree of homology, approximately 94%, with the native hormone. This structural similarity is crucial for its ability to mimic the action of GLP-1 in the body作者：R Tamayo-Trujillo·2024·被引用次数：71—Semaglutideis a drug with 94% homology with human GLP-1. Its chemicalstructureconsists of 31 amino acids with two amino acid substitutions ( ....

The precise molecular weight of semaglutide is a figure that has been calculated and verified through various scientific databases and research.Semaglutide | CAS# 910463-68-2 | GLP1 agonist Consistently, the values hover around 4113Molecularform: C187H291N45O59. Appearance: NA. Mol.Weight: 4113.64. Storage: 2-8°C Refrigerator. Shipping Conditions: Ambient. Applications:Semaglutideis a ....64 g/mol. Specifically, sources cite values such as 4113.作者：B Wasilewska·2025·被引用次数：3—Figure 8A shows the full Q1 mass scan spectrum ofsemaglutide. Due to the largemolecular weightofsemaglutide(m.w. = 4114), the authors ...641 g/mol, 4113.58 g/mol, 4114 g/mol, and approximately 4113.58 g/mol. Some sources provide a range, with the average mass often stated as 4113Molecular Formula. C187H291N45O ; Formula Weight.4113.6; Purity. ≥98% ; SMILES..641.Molecular formula: C187H290N45O59.Average mass: 4113.641. Monoisotopic mass: 4111.115377. ChemSpider ID: 34981134. 30 of 30 defined stereocenters. Variations in reported figures like 4113.63 or 4113,64 g/mol are typically due to rounding or minor differences in calculation methodologies. For a more precise indication, the monoisotopic mass is 4111.115377, offering an exact mass based on the most abundant isotopes of its constituent elements. It is important to distinguish this from the much larger 88277.935 Da figure, which may refer to a different context or a misinterpretation.

The chemical composition and resultant molecular weight are derived from the 31 amino acids that form the peptide chainMolecular formula: C187H290N45O59.Average mass: 4113.641. Monoisotopic mass: 4111.115377. ChemSpider ID: 34981134. 30 of 30 defined stereocenters.. These amino acids are linked together through peptide bonds, creating a polypeptide. The precise sequence of these amino acids and their side chains contribute to the overall mass of the molecule. For instance, specific amino acid substitutions, as seen in semaglutide's design, contribute to its enhanced stability and half-life compared to native GLP-1.

Semaglutide functions as a GLP-1 receptor agonist, meaning it binds to and activates the GLP-1 receptor in the body.Semaglutide This mechanism is central to its therapeutic effects. By activating these receptors, semaglutide influences several physiological processes, including stimulating insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety.Semaglutide | Drug Information, Uses, Side Effects ... These actions collectively contribute to improved glycemic control in individuals with type 2 diabetes and support weight management. The molecular weight plays a role in how the drug is absorbed, distributed, metabolized, and excreted within the body.

The molecular formula and molecular weight are critical parameters for pharmaceutical development, quality control, and regulatory approval. For instance, the PubChem database, a vital resource for chemical information, lists semaglutide with the CID 56843331 and confirms its molecular weight as 4114 g/mol. Similarly, NCIB Bookshelf and PDB-101 also provide valuable chemical data, with PDB-101 noting the molecular weight as 4113.Semaglutide 99% White powder weight loss641 g/mol.

Beyond the main semaglutide molecule, related entities also have their own defined chemical propertiesMolecular mechanisms of semaglutide and liraglutide as a .... For example, the Semaglutide side chain, a synthetic intermediate, has a different molecular formula (C43H79N3O13) and a distinct molecular weight of 846.10. This highlights the complexity of synthesizing such therapeutic peptides, where various components and intermediates are crucial.

In summary, the precise molecular weight of semaglutide is a well-established chemical characteristic, consistently reported around 4113.64 g/mol, with the molecular formula being C187H291N45O59. This intricate peptide structure underpins its function as a GLP-1 receptor agonist and its significant therapeutic applications in diabetes management and weight loss. Understanding this fundamental chemical property is vital for researchers, clinicians, and patients alike.