ribosomally synthesized and post-translationally modified peptides RiPPs are synthesized on ribosomes - Nrps Ribosomally synthesized and posttranslationally modified peptides Unveiling the World of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs)

Lassopeptides Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a rapidly expanding and incredibly diverse superfamily of natural products.Ribosomally synthesized and post-translationally modified ... These fascinating molecules, characterized by their synthesis on ribosomes followed by intricate post-translational modifications (PTMs), are gaining significant attention across various scientific disciplines. Their complex structures and potent biological activities make them promising candidates for drug discovery, particularly in areas like anticancer research, and offer immense potential for bioengineering applications.

The fundamental nature of ribosomally synthesized and post-translationally modified peptides lies in their production pathway.作者：G Zhong·2022·被引用次数：40—The biosynthesis of several classes ofribosomally synthesized and posttranslationally modified peptidesinvolves dehydration of serine and threonine residues. Unlike non-ribosomal peptides, RiPPs begin their journey as small, gene-encoded precursor proteins. These precursor molecules are then meticulously modified by a streamlined series of dedicated posttranslational modification (PTM) enzymes. This enzymatic machinery transforms the simple precursor into a highly structured and often bioactive peptide. The sheer diversity of these modifications, ranging from simple amino acid transformations to complex cyclizations and the formation of novel cross-links, contributes to the vast structural landscape of RiPPs. For instance, the biosynthesis of several classes of ribosomally synthesized and post-translationally modified peptides involves the dehydration of serine and threonine residues, a key step in creating unique structural motifs.作者：AL Vagstad·2023·被引用次数：22—RiPPs are generated by the maturation of small gene-encoded precursor proteinsby a streamlined series of posttranslational modification (PTM) enzymes.

One of the significant drivers behind the expansion of knowledge in this field is the advancement of genome mining software. These powerful tools enable researchers to analyze large-scale genomic data and identify novel biosynthetic gene clusters, facilitating the discovery of new RiPP classesRibosomally synthesized and post-translationally modified .... This genome mining approach has been particularly successful in uncovering unique biosynthetic pathways within fungi and other organisms.

The structural complexity of RiPPs gives rise to a wide array of biological activities作者：S Wang·2022·被引用次数：34—Ribosomally synthesized and post-translationally modified peptides(RiPPs) are structurally complex natural products with diverse bioactivities.. Beyond their well-documented anticancer properties, RiPPs exhibit antimicrobial, antifungal, and cytotoxic effects, making them valuable targets for pharmaceutical development.作者：PG Arnison·2013·被引用次数：2449—Covering: 1988 to 2012 This review presents recommended nomenclature for the biosynthesis ofribosomally synthesized and post-translationally modified peptides... The ability to uncover plant peptides as a distinct category, all of which are ribosomally synthesized and post-translationally modified peptides, further highlights their prevalence in nature and their potential as therapeutic agents.

The study of ribosomally synthesized and post-translationally modified peptides is not solely focused on discovery. Significant efforts are being dedicated to understanding their mechanisms of action in detail. For example, research into RiPPs containing C–C cross-links specifically as a result of post-translational modification is revealing intricate structural features that dictate their biological function. Furthermore, the field of protein engineering is actively exploring how to manipulate the biosynthesis of RiPPs for novel applications. This includes strategies for de novo design of ribosomally synthesized and post-translationally modified peptides, allowing for the creation of entirely new molecules with tailored properties.

The nomenclature surrounding ribosomally synthesized and post-translationally modified peptides has been a subject of focused effort, with recommended guidelines established to ensure clarity in discussing their biosynthesis. Established classes of RiPPs include lanthipeptides and lassopeptides, each with distinct structural and biosynthetic features. Another important group of enzymes involved in RiPP biosynthesis is the radical SAM enzymes, which play crucial roles in modifying these peptides作者：AL Vagstad·2023·被引用次数：22—RiPPs are generated by the maturation of small gene-encoded precursor proteinsby a streamlined series of posttranslational modification (PTM) enzymes.. The ThiF-like adenylyltransferase superfamily (TLATs), for instance, is essential for the biosynthesis of a diverse range of RiPPs.

The continuous exploration of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters and the advancement of engineering techniques promise to unlock even greater potential from this remarkable class of natural products.De novo design of ribosomally synthesized and post- ... As our understanding deepens, we can anticipate exciting breakthroughs in medicine and biotechnology stemming from these ribosome-made, post-translationally sculpted moleculesRadical SAM Enzymes in the Biosynthesis of Ribosomally .... The exploration of RiPPs review articles consistently showcases the rapid progress and exciting future of this field作者：H Li·2024·被引用次数：36—Ribosomally synthesized and post-translationally modified peptides(RiPPs) represent a diverse superfamily of natural products with immense ....